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Hospital

Departments

Biochemistry

The Department of Biochemistry is the heart of the medical institutions and provides feather to the institute by offering tremendous potential in basic as well as applied medical sciences. The Department of Biochemistry at Sri Muthukumaran Medical College Hospital and Research Institute was established in 2010. Biochemistry, the sole of medicine is an excellent and essential component of curriculum for all categories of health professionals. The Department has a well-equipped student lab, two demonstration halls and a seminar cum library room well equipped with textbooks and reputed journals. The Department has qualified, well experienced and passionate faculty who are committed to inspire the students in academics as well as research. The department trains the students in a clinical oriented manner so that they can apply their knowledge for patient care and to prepare for competitive exams. The faculties achieved many awards and prizes in various conferences and academic forum. Our department faculties are actively involved in various scientific societies at national and international level.

Diagnostics

Clinical Biochemistry Laboratory

Clinical Biochemistry tests comprises over one third of all hospital laboratory investigations. Clinical biochemistry is the branch of laboratory medicine in which chemical and biochemical methods are applied to the study of disease while in theory this embraces all non-morphological studies, in practice it is usually, though not exclusively, confined to studies on blood and urine because of the relative ease in obtaining such specimens although analysis are made on other body fluids such as pleural, gastric and cerebrospinal fluid.

Equipment's

Our clinical Biochemistry Laboratory is equipped with the following instruments providing 24 hours patients care services

  • Fully automated chemistry analyzer : Erba EM 200
  • Fully automated immunoassay system: MiniVidas
  • Semi automated analyzer: Erba Chem 7 and Merilyzer
  • Electrolyte analyzer: Starlyte
  • Arterial Blood Gas analyzer: Radiometer
  • Electrophoresis

List of Investigations

The following list of investigations are performed in our clinical biochemistry lab

Diabetic profile:

  • Fasting blood sugar (FBS)
  • Post-prandial blood sugar (PPBS)
  • Random blood sugar (RBS)
  • Oral glucose clearance test (OGCT)
  • Oral glucose tolerance test (OGTT)
  • Mean blood glucose (MBG)
  • Glycated hemoglobin (HbA1c)

Liver Function Test:

  • Total Bilirubin
  • Direct Bilirubin
  • Aspartate amino transferase (AST)
  • Alanine amino transferase (ALT)
  • Alkaline phosphatase (ALP)
  • Total Protein
  • Serum Albumin
  • Serum globulin
  • Albumin globulin ratio

Lipid profile:

  • Triglyceride
  • Total Cholesterol
  • HDL-Cholesterol
  • LDL-Cholesterol
  • VLDL-Cholesterol

Renal profile:

  • Urea
  • Creatinine
  • Uric acid

Electrolytes:

  • Sodium
  • Potassium
  • Chloride

Arterial blood Gases:

  • pH
  • pO2
  • pCo2
  • Calculated Bicarbonate

Other enzyme profile:

  • Amylase
  • Lactate dehydrogenase (LDH)

Cardiac profile:

  • Troponin – I
  • Lipid Profile

Coagulation profile:

  • Prothrombin time (PT)
  • Activated prothrombin time (APTT)
  • International normalized ratio (INR)

Bone profile:

  • Calcium
  • Phosphorus
  • Alkaline phosphatase (ALP)
  • Vitamin D3

Thyroid profile:

  • TSH
  • fT3
  • fT4

Fertility profile:

  • LH
  • FSH
  • Prolactin

COVID-19 Profile:

  • D-Dimer
  • Ferritin
  • LDH

Hormones

  • T. PSA

Urine profile:

  • Microprotein
  • Microalbumin
  • Protein creatinine ratio (PCR)
  • Urine Creatinine

Fluid analysis:

  • CSF (Sugar, Protein & LDH)
  • Pleural fluid (Sugar, Protein & LDH)
  • Peritoneal fluid (Sugar, Protein & LDH)
  • Synovial fluid (Sugar, Protein & LDH)

Services Offered

The biological patient’s samples were collected at different wards and out patients sample collection units by well trained technicians and release of reports within a appropriate turnaround time to enable early diagnosis and treatment.

  • Laboratory services for patients such as Clinical chemistry, Immunoassay, Electrolytes, Arterial blood gas analysis, urine analysis, coagulation profile, fluid analysis and special analytes.
  • Laboratory Internal Quality Control (IQC) is maintained with Bio-Rad quality control samples periodically.
  • External Quality Control program (EQAS) conducted by CMC, Vellore.
  • Biomedical waste
  • Water distillation unit for double distilled water .

Research

Equipments

Our Biochemistry Research Laboratory is equipped with the following instruments

  • PCR
  • Agarose Electrophoresis
  • SDS PAGE
  • Western Blotting unit
  • UV Spectophotometer

Major Research Protect:

Title of the Research proposal Antidiabetic potential of combinatorial herbal Formulation in high fat diet induced type 2 diabetic rats - a molecular approach
Funding Agency DST SERB –ECR Project, Government of India, Delhi.
Award Number ECR/2016/001579
Duration 3 years ( 2017 – 2020 )
Sanctioned Amount Rs. 32.32 lakhs

Ongoing Research:

Research articles are published every year in National and International journals by Faculties. Faculties are involved in the following research activities

1. Anti-diabetic activity

2. AI - derived predicted Glycated Hemoglobin (HbA1c) Values verses Laboratory - Derived Values

3. Cardio metabolic and endothelial dysfunction risk in hypertensive diabetic adults

Medical students are being encouraged and nurtured in Academics and Research.

Publications

S.No Faculty Name Publications
1. Dr. P. Mohanalakshmi

1. Thiagarajan sowmiya, Emmanuel Bhaskar, Veeraraghavan Gayathri, P. Mohanalakshmi, Santhi Silambanan The effect of Probiotic supplementation on the levels of biomarkers in diabetic animal model.
Journal of Clinical and Diagnostic Research, 2024 jun, vol-18(6):BK01- BK04

2. A. Jasmine chandra, B. Sudagar Singh, P. Mohanalakshmi, K. Maheshkumar, Santhi silambanan
Brain Natriuretic Peptide levels in Hypertensive Heart faillure patients with and without Diabetes Millitus: A cross-sectional study. Journal of Clinical and Diagnostic Research 2022

3. Nandhakumar E, Rahul G Mohanalakshmi P
Beneficial effect of poly herbal formulation (PHF) on altered glycoprotein components in high fat diet induced type 2 diabetic rats. International Journal of Advance and Innovative Research, 2021

4. K. Radharaja Prabhu, P. Mohanalakshmi, P. C. Chittambalam & A. Sathish Selvakumar
Case control evaluation of serum vitamin D levels in psoriasis Indian journal of clinical & experimental dermatology, 2019

5. Mohanalakshmi P & Muninathan N
Gender wise comparison of biochemical variables in normal individuals and chronic kidney disease patients with diabetes mellitus. Medpulse International Journal of Biochemistry, 2019

6. Mohanalakshmi P & Muninathan N
Uric acid as a biomarker for Pre diabetic & type 2 diabetic patients Scholars international journal of biochemistry, 2019

7. N. Muninathan P. Mohanalakshmi
Comparative study of glycoproteins in normal individuals and in patients with hypothyroidism and hyperthyroidism International Journal of clinical biochemistry and research, 2018

8. Mohanalakshmi P &Muthumeenakshi P
Effects of Swimming Combined Training on Lipid Profiles in male Adolescent Swimmers.
Journal of Medical Science and Clinical Research, 2016

9. N. Muninathan P. Mohanalakshmi
Effect of Paclitaxel along with Withnia Sominifera on Lactate dehydrogenase enzyme activity changes in 7, 12 Diethyl Benz (A) anthracene induced Breast cancer wistar rats.
Natural Journal of Medical research and Yoga Science, 2015

10. Dr.P.Mohanalakshmi, Dr. Santhi silambanan, Dr. R. Jothimalar. Correlation of Lipoprotein (a) in normal individuals and in chronic kidney patients with Diabetes Mellitus.
International Journal of Current Microbiology and Applied Sciences, 2014

11. Dr.N.Muninathan, Dr.P.Mohanalakshmi A combination of Paclitaxel and Diallyl sulfide on the activities of Mitrochondrial ezymes changes in 7, 12 dimethyl benz(a) anthracene induced skin cancer wistar rats.
International Journal of Current Biotechnology, 2014

12. Dr. P. Mohanalakshmi, Dr. Santhi Silambanan Comparative study of Lipoprotein (a) and lipid profile in Chronic kidney Disease patients on Hemodialysis and without Hemodialysis Journal of Evolution of medical and dental science, 2014

13. Dr. P. Mohanalakshmi, Dr. V. Madhubala, Dr. S. Malliga Hurler Scheie syndrome with subclinical hypothyroidism:Acase report International Journal of Biomedical and Advance Research, 2014

2. Dr. Nandhakumar E

1. Rahul Nandhakumar E. Primary phytochemical screening and in vitro antioxidant activity of methanol ethanol and aqueous extract of poly herbal formulation European Journal of Biomedical and Pharmaceutical Science, 2022

2. Rahul Nandhakumar E A Systematic review of five herbal incregrediants for the managements of diabetes mellitus.
Asian J Pharm Clin Res, 2022

3. Sundaram Ganesh V, Nandhakumar E, Muthu K. Hepatoprotective and anti-inflammatory potential of chebulagic acid on carbon tetrachloride–induced hepatic fibrosis by antioxidative activities in rats.
Comparative Clinical Pathology, 2021

4. Nandhakumar E, Rahul G, Mohanalakshmi P Beneficial effect of poly herbal formulation (PHF) on altered glycoprotein components in high fat diet induced type 2 diabetic rats.
International Journal of Advance and Innovative Research, 2021

5. Rahul G, Nandhakumar E, Renuka A. Effect of polyherbal drug on oxidative stress and insulin resistance in high-fat diet-induced type 2 diabetic rats.
All Life, 2020

6. Xianfu Sun, Periyakaruppan P, Naresj Kumar R, Nandhakumar E, Mariappan R
Natural deep eutectic solvent supported targeted solid–liquid polymer carrier for breast cancer therapy.
RSC advances, 2020

7. Rahul G, Nandhakumar E, Renuka A, Manamli A.
Antidiabetic potential of polyherbal drug against high-fat diet-induced type 2 diabetes mellitus male Wistar rats.
Drug Invention Today, 2019

8. Sundaram R, Nandhakumar E, Haseenabanu.
Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.
Toxicology Mechanisms and Methods, 2019

9. Vinothini K, Nareshkumar R, Ramu A, Nandhakumar E, M Rajan.
Folate receptor targeted delivery of paclitaxel to breast cancer cells via folic acid conjugated graphene oxide grafted methyl acrylate nanocarrier.
Biomedicine & Pharmacotherapy, 2019

10. IndumathiP, Nandhakumar E, Vijayalakshmi K
Histopathological and gene expression studies on sodium selenite induced cataract in wistar albino rats using perseaamericana&actinidiadeliciosa ethanol extracts.
International Journal of Pharmacy and Biological Sciences, 2018

11. Nandhakumar E, Indumathi P, Sachidanandam T P
Anticancer effect of methanolic extract of annonasquamosa on mammary carcinoma in rats with reference to glycoprotein components, lysosomal, and marker enzymes. Asian J Pharm Clin Res, 2017

12. Purushothaman A, Nandhakumar E, Shanthi P, Sachidanandam TP Shemamruthaa
A Herbal Formulation Induces Apoptosis in Breast Cancer Cells and Inhibits Tumor Progression in Rats.
Journal of Evidence-Based Complementary & Alternative Medicine. 2016

13. Suganthi S, HaseenaBanu H, Nandhakumar E, S Yamini Sudha Lakshmi
Hepatoprotective effect of ethanolic extract of whole plant of Andrographispaniculata against CCl4-induced hepatotoxicity in rats. Comparative Clinical Pathology 2015

14. Purushothaman A, Nandhakumar E, Shanthi P, Sachidanandam TP In vitro antioxidant potential of Shemamruthaa (a herbal formulation) and its anticancer activity in the MCF-7 cell line. RSC Advances, 2015.

15. Purushothaman A, Nandhakumar E, Shanthi P, Sachidanandam TP Antiproliferative and Apoptotic Effects of Shemamruthaa, a Herbal Preparation, in 7,12-Dimethylbenz(a)Anthracene-Induced Breast Cancer Rats.
Journal of Evidence-Based Complementary & Alternative Medicine, 2015.

16. Purushothaman A, Nandhakumar E, Shanthi P, Sachidanandam TP Shemamruthaa Herbal formulation modulates xenobiotic metabolizing enzymes and energy metabolism in 7, 12-Dimethylbenz [a] anthracene- induced breast cancer in rats.
Journal of Biochemical Technology, 2014.

17. Nandhakumar E, Purushothaman A, Sachdanandam P Acute and sub-acute toxicity studies using Shemamruthaa, a modified indigenous Siddha preparation, in Sprague-Dawleyrats.
Food Science and Biotechnology, 2014.

18. Purushothaman A, Nandhakumar E, Shanthi P, Sachidanandam TP Shemamruthaa A herbal formulation modulates xenobiotic and carbohydrate metabolizing enzymes in 7, 12-dimethylbenz [a] anthracene induced breast cancer in rat.
Journal of Biochemical Technology, 2014.

19. Nandhakumar E, Purushothaman A, Sachdanandam P Protective effect of Shemamruthaa on lipids anomalies in 7, 12- dimethylbenz [a] anthracene (DMBA)-induced mammary carcinoma- bearing rats.
Medicinal Chemistry Research, 2014

20. Nandhakumar E, Purushothaman A, Sachidanandam TP Free radical quenching effect of Shemamruthaa—a Siddha drug in 7, 12-dimethylbenz (a) anthracene-induced experimental breast cancer rats.
Comparative Clinical Pathology, 2014.

21. Nandhakumar E, P Indumathi
In vitro antioxidant activities of methanol and aqueous extract of Annonasquamosa (L.) fruit pulp Journal of acupuncture and meridian studies, 2013.

22. Purushothaman A, Nandhakumar E, Sachidanandam TP Phytochemical analysis and anticancer capacity of Shemamruthaa, a herbal formulation against DMBA-induced mammary carcinoma in rats.
Asian Pacific Journal of Tropical Medicine, 2013

23. Purushothaman A, Nandhakumar E, Sachidanandam TP Anticancer effect of Shemamruthaa (a phytochemical formulation) on 7, 12-dimethylbenz (a) anthracene induced mammary carcinoma in rats. Asian J Pharm Clin Res, 2012.

24. Purushothaman A, Nandhakumar E, Sachidanandam TP Modulation of lipid peroxidation and antioxidant status upon administration of ‘Shemamruthaa’in 7, 12-dimethylbenz [a] anthracene induced mammary carcinoma bearing rats.
Asian Pacific Journal of Tropical Biomedicine, 2012.

25. Purushothaman A, Nandhakumar E, Sachidanandam TP Modulatory effect of Shemamruthaa, a phytochemical combinant against DMBA-induced oxidative damage in mammary carcinoma rats.
Asian pacific Journal of Tropical Biomedicine, 2012.

3. Dr. Akila S

1. Deepti R & Akila S.
Assessment of uric acid status in obese individuals.
Ejpmr, 2020.

2. Akila S & Deepti R Etiology of cancer: A deadly ocean Ejpmr, 2020.

3. S. Akila, P. Pullaiah, R.Deepti and L . Ramesh Bharathi. Influence of age and gender on renal function by using eGFR in healthy population.
European journal of Biomedical and pharmaceutical science, 2018.

4. S. Akila, R.Deepti and L . Ramesh
Bharathi.Cancer cell and its oncometabolites.
Asian Journal of pharmaceutical research. 2018

5. S. Akila, R.Deepti and L . Ramesh Bharathi. Mrs. B. Saritha & Dr. A. Renuka
The impact of increased serum GGT levels and NAFLD on the components of metabolic syndrome.
Journal of current trends in clinical medicine and laboratory biochemistry, 2015.

6. Mrs. S.Akila
Prevalence of Metabolic Syndrome and its components in women with subclinical hypothyroidism
Asian journal of Pharmaceutical research, 2013.

CME, Conference & Workshop

CME – BIOMAGIC 2025 on April 25th 2025

Seminar – Quality control in clinical biochemistry Laboratory on March 21st 2025

Achievements And Awards

Dr. E. Nandhakumar –Young Achiever Award 2020, Best Oral & Best Poster Presentation.

Head of the Department

Prof. Dr. P. Mohanalakshmi MBBS.,MD

List of faculties